LAUSR

This paper reported a simple method for sulfanilamide determination by redox process electroanalysis of oxidation products (SFDox) formed in situ on glassy carbon electrode. The CV experiments showed a reversible process after applied Eacc = + 1.06 V and tacc = 1 s, in 0.1 mol L−1 BRBS (pH = 2.0) at 50 mV s−1. Different voltammetric scan rates (from 10 to 450 mV s−1) suggested that the redox peaks of SFDox on the glassy carbon electrode (GCE) is an adsorption-controlled process. Square-wave voltammetry (SWV) method optimized conditions showed a linear response to SFD from 3.00 to 250.0 μmol L−1 (R = 0.998) with a limit of detection of 0.638 μmol L−1 and limit of quantification of 2.0 μmol L−1. The developed the SWV method was successfully used in the determination of SFD pharmaceutical formulation and human serum. The SFD quantification results in pharmaceutical obtained by SWV-GCE were comparable to those found by official analytical protocols.