LAUSR

Recently, Camptocormia raised some interest as a motor neuron disease symptom as shown in a recent letter [1]. We read on the Neurological Sciences journal that piece, entitled BCamptocormia as presenting in lower motor neuron disease with TARDBP mutation: case report^. We think that this letter, reporting a case report, is worthy of stronger methodological support. Some reflections on this piece point out what is yet necessary to do to support authoritatively the effectiveness of its approach. Particularly, the methodological approach shows some severe flaws, which might undermine result interpretation. Therefore, this letter aims at suggesting the study’s improvements to achieve stronger conclusions on the treated matter. In introduction, the authors wrote: BMutations in the TARDBP gene were detected in 1%...^, but this result was not confirmed by Scotter et al. [2], despite the authors citing their article. Not to mention the fact that in some cases such a small percent value could be mistaken for a Bsignal^ while being more likely a Bnoise^ [3]. Furthermore, the authors omit to provide any data about: