LAUSR

Dear Editor, Paraneoplastic syndrome can present with diverse manifestations in various organs. Molecular mimicry is believed to underlie the development of the paraneoplastic syndromes [1]. Paraneoplastic optic neuropathy (PON) and cancerassociated retinopathy (CAR), the most common ocular presentations of paraneoplastic syndrome, are diagnosed based on the clinical presentation in the setting of an underlying malignancy and the detection of pathogenic autoantibodies such as collapsin response-mediator protein-5 (CRMP-5) antibody [2] and recoverin antibody [3]. The CRMP-5 antibody is the most frequently implicated antibody in PON and usually induces optic neuritis accompanied by retinal vascular leakage and vitritis [4]. The cancers which are known to be associated with PON include small-cell lung carcinoma [4, 5] and lymphoma [6]. On the other hand, recoverin is one of the retinal antigens located within retinal photoreceptors and is related to CAR. Pathogenic recoverin autoantibodies’ main manifestation is macular atrophy associated with photoreceptor loss [7], retinal vasculitis [8], and pigment epithelial degeneration [9]. Herein, we report the first case of bilateral optic neuropathy in a patient with pancreatic ductal adenocarcinoma who was positive for autoantibody against recoverin. Case report