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Neurophysiological challenges in myasthenia gravis associated with MuSK antibodies: a case report

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Repetitive nerve stimulation (RNS) in limb muscles has low sensitivity in myasthenia gravis with muscle-specific tyrosine kinase antibodies (MuSK-MG) given the predominant involvement of cranial and neck muscles [1, 2].… Click to show full abstract

Repetitive nerve stimulation (RNS) in limb muscles has low sensitivity in myasthenia gravis with muscle-specific tyrosine kinase antibodies (MuSK-MG) given the predominant involvement of cranial and neck muscles [1, 2]. However, when affected muscles (i.e., facial muscles) are tested, the RNS positivity rate in MuSK-MG can be as high as 83–87% [3]. Here, we report a patient in whom electrophysiological findings challenge the accepted concept that in MG, RNS is generally abnormal in clinically weak muscles.

Keywords: gravis associated; myasthenia gravis; report; gravis; neurophysiological challenges; challenges myasthenia

Journal Title: Neurological Sciences
Year Published: 2022

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