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Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as… Click to show full abstract
Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as the hierarchical organization into leader (tip) and follower (stalk) cells via a dynamic interplay with Notch. Recent studies reveal novel molecular mechanisms to fine-tune VEGF/Notch signaling and tip/stalk cell function during sprouting angiogenesis.
Keywords:
stalk cell;
tip stalk;
angiogenesis;
sprouting angiogenesis
Journal Title: Angiogenesis
Year Published: 2020
Link to full text (if available)
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Journal Title: Angiogenesis
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!