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We studied combined effect of β-hairpin antimicrobial peptide tachyplesin I and cytotoxic agent cisplatin on tumor and normal human cell lines. MTT assay and flow cytometry showed that tachyplesin I… Click to show full abstract
We studied combined effect of β-hairpin antimicrobial peptide tachyplesin I and cytotoxic agent cisplatin on tumor and normal human cell lines. MTT assay and flow cytometry showed that tachyplesin I selectively sensitized cancer cells to cisplatin in specified concentration ratios. In vitro experiments demonstrated that combined use of tachyplesin I and cisplatin allows decreasing the effective dose of the cytostatic thus reducing nonspecific toxicity.
Keywords:
tachyplesin;
cisplatin;
peptide tachyplesin;
effect;
antimicrobial peptide
Journal Title: Bulletin of Experimental Biology and Medicine
Year Published: 2018
Link to full text (if available)
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Journal Title: Bulletin of Experimental Biology and Medicine
Year Published: 2018
Link to full text (if available)
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recommendations!