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Abstract We report herein the synthesis of N -substituted indoles resulting from the ring-closing metathesis of indole precursors bearing N -terminal alkenes. The aqueous metathesis of the indole precursors gave… Click to show full abstract
Abstract We report herein the synthesis of N -substituted indoles resulting from the ring-closing metathesis of indole precursors bearing N -terminal alkenes. The aqueous metathesis of the indole precursors gave good yields of N -substituted indoles (up to 72%) with commercial metathesis catalysts and with artificial metalloenzymes based on the biotin-streptavidin technology. Strikingly, the yield of the N -acetylindole increases in presence of a second metathesis substrate. Graphic Abstract
Keywords:
metathesis;
synthesis substituted;
closing metathesis;
substituted indoles;
ring closing
Journal Title: Catalysis Letters
Year Published: 2020
Link to full text (if available)
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Journal Title: Catalysis Letters
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!