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Explosive Blast Loading on Human 3D Aggregate Minibrains

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The effects of primary explosive blast on brain tissue still remain mostly unknown. There are few in vitro models that use real explosives to probe the mechanisms of injury at… Click to show full abstract

The effects of primary explosive blast on brain tissue still remain mostly unknown. There are few in vitro models that use real explosives to probe the mechanisms of injury at the cellular level. In this work, 3D aggregates of human brain cells or brain microphysiological system were exposed to military explosives at two different pressures (50 and 100 psi). Results indicate that membrane damage and oxidative stress increased with blast pressure, but cell death remained minimal.

Keywords: blast; blast loading; aggregate minibrains; human aggregate; explosive blast; loading human

Journal Title: Cellular and Molecular Neurobiology
Year Published: 2017

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