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Synthesis and antioxidant activity of some new N-alkylated pyrazole-containing benzimidazoles

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A series of new N-substituted pyrazole-containing benzimidazoles was synthesized starting from 1,2-diaminobenzene and pyrazole-4-carbaldehyde in good yield. Antioxidant activity of all title compounds was assessed using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide… Click to show full abstract

A series of new N-substituted pyrazole-containing benzimidazoles was synthesized starting from 1,2-diaminobenzene and pyrazole-4-carbaldehyde in good yield. Antioxidant activity of all title compounds was assessed using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide assays. Some of the synthesized compounds having benzyl substituent at the imidazole nitrogen exhibited good activity in both assays.

Keywords: antioxidant activity; activity new; containing benzimidazoles; synthesis antioxidant; pyrazole containing; activity

Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2017

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