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Noncatalytic destruction of 5-acylcomanic acid esters in the presence of 2-methylindoles as a new method for the synthesis of indolylchalcones

Ethyl esters of 5-acylcomanic acids reacted with 2-methylindoles in 3:1 propanol–water mixture in the absence of catalyst, resulting in pyrone ring opening and destruction of the molecular framework and leading… Click to show full abstract

Ethyl esters of 5-acylcomanic acids reacted with 2-methylindoles in 3:1 propanol–water mixture in the absence of catalyst, resulting in pyrone ring opening and destruction of the molecular framework and leading to trans-indolylchalcones in 52–70% yields.

Keywords: noncatalytic destruction; destruction acylcomanic; acid esters; destruction; esters presence; acylcomanic acid

Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2017

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