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Use of Hypervalent Iodine in the Synthesis of Isomeric Dihydrooxazoles

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A convenient synthesis of 2- and/or 3-oxazolines has been developed depending on the structure and stereochemistry of the starting amino alcohol. PhI(OAc)2 acted as oxidant on the intermediate imine, as… Click to show full abstract

A convenient synthesis of 2- and/or 3-oxazolines has been developed depending on the structure and stereochemistry of the starting amino alcohol. PhI(OAc)2 acted as oxidant on the intermediate imine, as supported by NMR investigation. The findings demonstrate a new route providing access to unusual 3-oxazolines.

Keywords: use hypervalent; hypervalent iodine; isomeric dihydrooxazoles; synthesis isomeric; iodine synthesis; synthesis

Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2018

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