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It is shown that alkylation of pyrazoles with (E)/(Z)-1,3-dichlorobut-2-enes can be carried out in an alkaline aqueous medium in the presence of N-methylmorpholine N-oxide. In some cases, this technique may… Click to show full abstract
It is shown that alkylation of pyrazoles with (E)/(Z)-1,3-dichlorobut-2-enes can be carried out in an alkaline aqueous medium in the presence of N-methylmorpholine N-oxide. In some cases, this technique may substitute phase-transfer catalysis. Conformational analysis of the reaction products showed that a mixture of (E)/(Z) isomers is formed in a ratio of 9:1.
Keywords:
medium;
alkylation pyrazoles;
aqueous methylmorpholine;
methylmorpholine oxide
Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2018
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Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2018
Link to full text (if available)
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recommendations!