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Synthesis and antimycobacterial activity of pyridinium compounds with sulfonylacetamide substituent in N-alkyl chain

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Pyridines containing amine, amide, or hydrazide substituent were quaternized with (ω-haloalkyl)sulfonylacetamides, resulting in new pyridinium compounds that exhibited tuberculostatic activity against the strain H37Rv of Mycobacterium tuberculosis. Click to show full abstract

Pyridines containing amine, amide, or hydrazide substituent were quaternized with (ω-haloalkyl)sulfonylacetamides, resulting in new pyridinium compounds that exhibited tuberculostatic activity against the strain H37Rv of Mycobacterium tuberculosis.

Keywords: pyridinium compounds; antimycobacterial activity; substituent; synthesis antimycobacterial

Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2018

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