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O-cyclialkylation of substituted bis[3-hydroxy-2-(pyrimidin-2-yl)-2H-pyrazol-4-yl]methane by α,ω-dibromoalkanes with a hydrocarbon chain length of up to three CH2 groups has been carried out. A novel pyrazolophane, 1,6-dioxacycloundecane with symmetrically annulated fragments of… Click to show full abstract
O-cyclialkylation of substituted bis[3-hydroxy-2-(pyrimidin-2-yl)-2H-pyrazol-4-yl]methane by α,ω-dibromoalkanes with a hydrocarbon chain length of up to three CH2 groups has been carried out. A novel pyrazolophane, 1,6-dioxacycloundecane with symmetrically annulated fragments of 1-(pyrimidin-2-yl)-1H-pyrazole, was isolated and characterized as a result of this reaction. The precursor bridged heterocycle was obtained by condensation of the corresponding 2-(pyrimidin-2-yl)-2H-pyrazol-3-ol with formaldehyde in a 2:1 molar ratio.
Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2018
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