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A series of 1,3-disubstituted ureas containing 1,3,5-trisubstituted pyrazole and (adamantan-1-yl)methyl fragments were synthesized in the reaction of 1-(isocyanatomethyl)adamantane with 3- or 4-aminopyrazoles under mild conditions in 67-92% yields. The inhibitory… Click to show full abstract
A series of 1,3-disubstituted ureas containing 1,3,5-trisubstituted pyrazole and (adamantan-1-yl)methyl fragments were synthesized in the reaction of 1-(isocyanatomethyl)adamantane with 3- or 4-aminopyrazoles under mild conditions in 67-92% yields. The inhibitory activity of the obtained compounds with respect to human soluble epoxide hydrolase (sEH) was 16.2-50.2 nmol/l, with solubility in water of 45-85 μmol/l.
Keywords:
methyl;
adamantan methyl;
synthesis properties;
pyrazolyl ureas;
methyl pyrazolyl;
properties adamantan
Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2019
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Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2019
Link to full text (if available)
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recommendations!