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4-Acyl-2-amino-6-chloropyridine-3,5-dicarbonitriles underwent heterocyclization in the presence of ammonia in aqueous dioxane medium, involving the ortho-ketonitrile fragment while preserving the halogen atom. The pyrrole ring annulation process proceeded regioselectively with the… Click to show full abstract
4-Acyl-2-amino-6-chloropyridine-3,5-dicarbonitriles underwent heterocyclization in the presence of ammonia in aqueous dioxane medium, involving the ortho-ketonitrile fragment while preserving the halogen atom. The pyrrole ring annulation process proceeded regioselectively with the formation of a single positional isomer.
Keywords:
pyrrole ring;
annulation pyrrole;
acylpyridine dicarbonitriles;
ring acylpyridine;
presence ammonia
Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2019
Link to full text (if available)
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Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2019
Link to full text (if available)
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recommendations!