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Synthesis of benzo[c][1,7]naphthyridine derivatives

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Reactivity of 2-methyl-6-phenylbenzo[c][1,7]naphthyridine in alkylation, oxidation, and electrophilic substitution reactions has been studied. The reaction of 2-methyl-6-phenylbenzo[c][1,7]naphthyridines with POCl3 yielded the previously unknown 4-chloro-2-methyl-6-phenylbenzo[c][1,7]naphthyridine. Its dehalogenation and substitution of halogen… Click to show full abstract

Reactivity of 2-methyl-6-phenylbenzo[c][1,7]naphthyridine in alkylation, oxidation, and electrophilic substitution reactions has been studied. The reaction of 2-methyl-6-phenylbenzo[c][1,7]naphthyridines with POCl3 yielded the previously unknown 4-chloro-2-methyl-6-phenylbenzo[c][1,7]naphthyridine. Its dehalogenation and substitution of halogen by nitrogen and sulfur nucleophiles were studied.

Keywords: naphthyridine derivatives; benzo naphthyridine; methyl phenylbenzo; synthesis benzo

Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2019

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