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The efficient approach to novel water-soluble 2-aryl-substituted N-(phosphorylmethyl)pyrrolidines via acid-catalyzed elimination/cyclization/Friedel–Crafts reaction sequence of {[(4,4-diethoxybutyl)amino]methyl}phosphonates is proposed. Zwitterionic structure of N-(phosphorylmethyl) pyrrolidines has been proved by X-ray crystallography. Click to show full abstract
The efficient approach to novel water-soluble 2-aryl-substituted N-(phosphorylmethyl)pyrrolidines via acid-catalyzed elimination/cyclization/Friedel–Crafts reaction sequence of {[(4,4-diethoxybutyl)amino]methyl}phosphonates is proposed. Zwitterionic structure of N-(phosphorylmethyl) pyrrolidines has been proved by X-ray crystallography.
Keywords:
phosphorylmethyl pyrrolidines;
elimination cyclization;
cyclization friedel;
pyrrolidines via;
acid catalyzed;
via acid
Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2020
Link to full text (if available)
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Journal Title: Chemistry of Heterocyclic Compounds
Year Published: 2020
Link to full text (if available)
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recommendations!