Two new isocoumarins, tabaisocoumarins D and E (1 and 2), together with four known isocoumarins (3–6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means… Click to show full abstract
Two new isocoumarins, tabaisocoumarins D and E (1 and 2), together with four known isocoumarins (3–6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1, 2, 5, and 6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results revealed that compounds 1, 2, 5, and 6 showed potential anti-TMV activities with inhibition rate of 26.8, 25.4, 22.6, and 23.5%, respectively.
               
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