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Isocoumarins from the Leaves of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activities

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Two new isocoumarins, tabaisocoumarins D and E (1 and 2), together with four known isocoumarins (3–6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means… Click to show full abstract

Two new isocoumarins, tabaisocoumarins D and E (1 and 2), together with four known isocoumarins (3–6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1, 2, 5, and 6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results revealed that compounds 1, 2, 5, and 6 showed potential anti-TMV activities with inhibition rate of 26.8, 25.4, 22.6, and 23.5%, respectively.

Keywords: tobacco mosaic; leaves nicotiana; mosaic virus; anti tobacco; nicotiana tabacum

Journal Title: Chemistry of Natural Compounds
Year Published: 2017

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