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9H-[1,2,4]Triazolo[4,3-g]purin-5-amine (2) was synthesized by reaction of 6-hydrazinyl-7H-purin-2-amine (1a) with formic acid under reflux conditions. Treating compound 1a in ethanol with CS2 in the presence of KOH yielded 5-amino-3H-[1,2,4]triazolo[4,3-g]purine-3-thione (3).… Click to show full abstract
9H-[1,2,4]Triazolo[4,3-g]purin-5-amine (2) was synthesized by reaction of 6-hydrazinyl-7H-purin-2-amine (1a) with formic acid under reflux conditions. Treating compound 1a in ethanol with CS2 in the presence of KOH yielded 5-amino-3H-[1,2,4]triazolo[4,3-g]purine-3-thione (3). The new synthesized compounds were characterized using IR, 1H NMR, and elemental analysis. The synthesized compounds have been screened for antibacterial activity.
Keywords:
containing purine;
evaluation triazole;
triazole compounds;
compounds containing;
vitro antibacterial;
antibacterial evaluation
Journal Title: Chemistry of Natural Compounds
Year Published: 2017
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Journal Title: Chemistry of Natural Compounds
Year Published: 2017
Link to full text (if available)
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recommendations!