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Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme… Click to show full abstract
Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.
Keywords:
dna phosphodiesterase;
repair enzyme;
dna repair;
dna;
enzyme tyrosyl;
tyrosyl dna
Journal Title: Chemistry of Natural Compounds
Year Published: 2018
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Journal Title: Chemistry of Natural Compounds
Year Published: 2018
Link to full text (if available)
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recommendations!