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A new flavone, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone (1), has been isolated from the leaves of Nicotiana tabacum, together with five known compounds, 8-formyl-4′-hydroxy-6,7-dimethoxyflavone (2), quercetin (3), (2R,3R)-3,5-dihydroxy-7-methoxyflavanone (4), kaempferol (5), and rutin (6).… Click to show full abstract
A new flavone, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone (1), has been isolated from the leaves of Nicotiana tabacum, together with five known compounds, 8-formyl-4′-hydroxy-6,7-dimethoxyflavone (2), quercetin (3), (2R,3R)-3,5-dihydroxy-7-methoxyflavanone (4), kaempferol (5), and rutin (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, 8-formyl-7-hydroxy-6,4′-dimethoxyflavone (1) and 8-formyl-4′-hydroxy-6,7-dimethoxyflavone (2) exhibited cytotoxicities, with IC50 values of 2.24 ± 0.32 and 3.40 ± 0.21 μg/mL, respectively, against CCRF-CEM and P388D1 cell lines.
Journal Title: Chemistry of Natural Compounds
Year Published: 2018
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