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A new aurone, named (Z)-4,5-methylenedioxy-6-hydroxybenzene-2[(2′,3′,4′-trimethoxy)-2-methyl-2(4-methyl-3-penten-1-yl)-2H-1-benzopyran-5-yl)methylene]-3-benzofuranon (1), and nine known aurones (2–10) were isolated from Sophora japonica L. for the first time. Compounds 1–10 were evaluated for their neuroprotective activities against… Click to show full abstract
A new aurone, named (Z)-4,5-methylenedioxy-6-hydroxybenzene-2[(2′,3′,4′-trimethoxy)-2-methyl-2(4-methyl-3-penten-1-yl)-2H-1-benzopyran-5-yl)methylene]-3-benzofuranon (1), and nine known aurones (2–10) were isolated from Sophora japonica L. for the first time. Compounds 1–10 were evaluated for their neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells. Compounds 1, 3, 8, and 10 exhibited significant neuroprotective activities with IC50 values in the range of 2.89–6.02 μM.
Journal Title: Chemistry of Natural Compounds
Year Published: 2019
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