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A new isochromeno[4,3-b]chromen-7(5H)-one derivative, 8-hydroxy-3,10-dimethoxyisochromeno [4,3-b]chromen-7(5H)-one (1), has been isolated from the aerial part of Filipendula kiraishiensis, together with seven known compounds. The structure of the new compound 1 was… Click to show full abstract
A new isochromeno[4,3-b]chromen-7(5H)-one derivative, 8-hydroxy-3,10-dimethoxyisochromeno [4,3-b]chromen-7(5H)-one (1), has been isolated from the aerial part of Filipendula kiraishiensis, together with seven known compounds. The structure of the new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, luteolin (2), rutin (3), quercetin (4), and isoquercitrin (5) showed potent inhibition with IC50 values of 24.2 ± 1.2, 18.6 ± 1.3, 10.2 ± 0.5, and 12.2 ± 1.0 μM, respectively, against LPS-induced NO generation. In addition, 8-hydroxy-3,10-dimethoxyisochromeno[4,3-b]chromen-7(5H)-one (1) exhibited anti-Dengue virus activities with IC50 value of 22.4 ± 1.6 μM against Dengue virus serotype 2 strain PL046.
Journal Title: Chemistry of Natural Compounds
Year Published: 2019
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