Photo from archive.org
28-Oxo-allobetulone derivatives that were newly synthesized or prepared earlier by modification of ring A (3- and 4-pyridylidene, furfurylidene, azepane, lactam, quinolone, spiroindole, pyrazole, isoxazole, and tetraoxane derivatives) and 3 β… Click to show full abstract
28-Oxo-allobetulone derivatives that were newly synthesized or prepared earlier by modification of ring A (3- and 4-pyridylidene, furfurylidene, azepane, lactam, quinolone, spiroindole, pyrazole, isoxazole, and tetraoxane derivatives) and 3 β ,19 β ,28-oleantriol were tested in vitro for cytotoxicity against 60 cell lines of 9 human tumor types. Melanoma SK-MEL-5 and CNS SNB-75 cancer cells died in the presence of 3- or 4-pyridylidene derivatives of 28-oxo-allobetulone. 3 β ,19 β ,28-Oleantriol possessed selective cytotoxicity against CNS cancer cell line SNB-75.
Journal Title: Chemistry of Natural Compounds
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!