LAUSR

Hydatidiform mole, also known as molar pregnancy, occurs in approximately one in every 600–800 pregnancies [1–3] and is the result of a genetic abnormality that causes growth of atypical in uterohyperplastic trophoblasts and hydropic villi. After one, or two consecutive, complete hydatidiform moles (CMs), the risks of a subsequent CM are 1 in 100 or 1 in 4, respectively; a partial hydatidiform mole (PM) only slightly increases the risk of a subsequent molar pregnancy [4]. Molar pregnancies carry the risk of the development of gestational trophoblastic neoplasia (GTN), with approximately 10% of patients with CM and 1% of patients with PM requiring chemotherapy for GTN [2]. van der Ven et al. reported an 8–10% incidence of PM following assisted reproductive procedures [5], including intracytoplasmic sperm injection (ICSI). Here, we describe a rare case of a patient who experienced a live euploid birth and spontaneous CM, followed by PM after ICSI.