LAUSR

Major Depression Disorder (MDD) is a common mental disorder that negatively affects many people’s lives worldwide. Developing an automated method to find useful diagnostic biomarkers from brain imaging data would help clinicians to detect MDD in its early stages. Depression is known to be a brain connectivity disorder problem. In this paper, we present a brain connectivity-based machine learning (ML) workflow that utilizes similarity/dissimilarity of spatial cubes in brain MRI images as features for depression detection. The proposed workflow provides a unified framework applicable to both structural MRI images and resting-state functional MRI images. Several cube similarity measures have been explored, including Pearson or Spearman correlations, Minimum Distance Covariance, or inverse of Minimum Distance Covariance. Discriminative features from the cube similarity matrix are chosen with the Wilcoxon rank-sum test. The extracted features are fed into machine learning classifiers to train MDD prediction models. To address the challenge of data imbalance in MDD detection, oversampling is performed to balance the training data. The proposed workflow is evaluated through experiments on three independent public datasets, all imbalanced, of structural MRI and resting-state fMRI images with depression labels. Experimental results show good performance on all three datasets in terms of prediction accuracy, specificity, sensitivity, and area under the Receiver Operating Characteristic (ROC) curve. The use of features from both structured MRI and resting state functional MRI is also investigated.