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The purpose of this novel research is to explore the formation of inclusion complexes of a drug, namely, chloroquine diphosphate with cyclic oligosaccharides. The solubility, versatility and bioavailability of the… Click to show full abstract
The purpose of this novel research is to explore the formation of inclusion complexes of a drug, namely, chloroquine diphosphate with cyclic oligosaccharides. The solubility, versatility and bioavailability of the drug are enhanced and some of its side effects are reduced after encapsulation. Various sophisticated approaches have been employed to synthesize and characterize the inclusion phenomenon, which confirm the 1:1 stoichiometry of the complexes. The association constant is found higher in case of β-cyclodextrin which was explicated based on their molecular structure. The work explores the enhancement of overall bioavailability of this essential biologically active molecule.
Journal Title: Journal of Inclusion Phenomena and Macrocyclic Chemistry
Year Published: 2020
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