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SARS-CoV-2 Infection in a Child with Severe Congenital Neutropenia

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The global pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has resulted in unprecedented anxiety and fear among many patient communities, especially those with underlying immunological perturbations. From the… Click to show full abstract

The global pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has resulted in unprecedented anxiety and fear among many patient communities, especially those with underlying immunological perturbations. From the very beginning of this novel virus outbreak in the community, clinical immunologists were on high alert to understand the natural course of illness and identify optimal management protocols in patients with inborn errors of immunity (IEI) who developed SARS-CoV-2 infection [1, 2]. Studying the natural course of SARS-CoV-2 infection in patients with IEI would reveal the significance of underlying redundant immunological pathways in pathogenesis of infection. Recent studies have shown that the risk of acquiring SARS-CoV-2 infection and infection-related mortality rates in patients with IEI is similar to the general population. However, a particular group of patients with IEI also had a severe infection and fulminant course. In this context, we share our experience of SARS-CoV-2 infection in a child with severe congenital neutropenia (SCN). Case Details

Keywords: infection; severe congenital; infection child; child severe; sars cov; cov infection

Journal Title: Journal of Clinical Immunology
Year Published: 2021

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