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A mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative treatment against a glioma

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In this paper, we propose a mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative to treatment of a glioma. The main idea is to incorporate the virotherapy… Click to show full abstract

In this paper, we propose a mathematical model that combines chemotherapy and oncolytic virotherapy as an alternative to treatment of a glioma. The main idea is to incorporate the virotherapy after the first or second chemotherapy session using a specialist virus that attacks only tumor cells. Some simulations are presented. Based on the results, we conclude that with this combined therapy may reduce the number of chemotherapy sessions and may lead to obtain better results in the fight against gliomas.

Keywords: oncolytic virotherapy; combines chemotherapy; chemotherapy oncolytic; virotherapy; model combines; mathematical model

Journal Title: Journal of Mathematical Chemistry
Year Published: 2019

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