LAUSR

Mesoporous silica nanoparticles (MSNs) were prepared using sol–gel method. Chitosan-MSNs microspheres scaffold loaded with ciprofloxacin also prepared via an ionotropic gelation method. The prepared samples were characterized using FE-SEM, TEM, FTIR and XRD analysis. The pore volume and mean pore diameter for MSNs was determined by the Brunauer–Emmett–Teller (BET) method. The in vitro drug test was evaluated by using UV–Vis spectrophotometry at λ max of 275 nm. The estimated (measured) MSNs pore volume and pore diameter were 0.9227 cm 3 /g and 2.6058 nm, respectively. The Chitosan-MSNs loaded with ciprofloxacin show a spherical surface with good and uniform distribution of the MSNs in the microspheres. The in vitro drug release confirms that the MSNs containing beads shows a retarding release (≈ 90% in 9 h) than beads without MSNs (≈ 90% in 2 h). In the light of these findings, the developed delivery system scaffold holds great potential for bone regeneration by control drug release used in activation osteoblast cells.