LAUSR

The characterizations and physical properties of elastomeric poly(glycerol sebacate) (PGS) copolymerized with different amounts of polyhydroxybutyrate diol (PHB-diol) were analyzed with 1H-NMR, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), mechanical test, biodegradation test, and cytotoxicity analysis. The chemical composition of the PHB-diol prepared and the copolymerization reaction of the PHB-diol in the PGS were confirmed by 1H-NMR. From 1H-NMR analysis, the PHB-diol prepared had the molecular weight about 989.6 g/mol and a faster crystallization rate than the PHB according to the DSC measurement. The tensile/compressive strengths of PGS-co-(PHB-diol) increased while the crosslinking densities decreased with the amount of PHB-diol copolymerized. The PGS-co-(PHB-diol) had a slower biodegradation rate but a worse thermal stability than the PGS. Additionally, the biodegradable PGS-co-(PHB-diol) elastomers prepared exhibited no cytotoxicity and could replace PGS used in bio-fields.