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Zirconium-89 has attracted huge interests and is used in tracing and quantification of slow biological processes and labeling of long half-live biomolecules such as monoclonal antibodies for pharmacokinetic studies and… Click to show full abstract
Zirconium-89 has attracted huge interests and is used in tracing and quantification of slow biological processes and labeling of long half-live biomolecules such as monoclonal antibodies for pharmacokinetic studies and clinical trials. In this review, a concise introduction to targetry, irradiation data, separation and coordination chemistry of zirconium-89 has been presented. A detailed overreviwew on bi-functional ligands conjugation and 89Zr radiolabeling been addressed. The latest status of preclinical as well as clinical trials using 89Zr radioimmunomolecules in various human diseases has been presented since 2012.
Journal Title: Journal of Radioanalytical and Nuclear Chemistry
Year Published: 2017
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