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O-(1′-[18F]fluoropropan-2′-yl)-l-tyrosine (1-[18F]FPT) was synthesized using the Ni(II)-(S)-[N-2-(N′-benzylprolyl)amino]benzophenone-S-tyrosine based precursor. The precursor was synthesized through a two-step process starting from RS-tyrosine, (S)BPB and Ni(II) chloride hexahydrate. The precursor was [18F]radiofluorinated, followed by… Click to show full abstract
O-(1′-[18F]fluoropropan-2′-yl)-l-tyrosine (1-[18F]FPT) was synthesized using the Ni(II)-(S)-[N-2-(N′-benzylprolyl)amino]benzophenone-S-tyrosine based precursor. The precursor was synthesized through a two-step process starting from RS-tyrosine, (S)BPB and Ni(II) chloride hexahydrate. The precursor was [18F]radiofluorinated, followed by hydrolysis with 2 M HCl to obtain 1-[18F]FPT. The reaction mixture was purified using neutral alumina column. Radiolabeling efficiency and radiochemical yield (after purification and decay uncorrected) was 60 and 5% respectively. Total time for synthesis was 70 min. This synthesis procedure for (1-[18F]FPT) gave a radiochemical purity of 98% with enantiomeric purity of 93%, and can easily be adapted in any standard 2-[18F]FDG synthesis module.
Journal Title: Journal of Radioanalytical and Nuclear Chemistry
Year Published: 2017
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