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In this study, we introduce a new 99mTc-radiolabeled bombesin derivative for imaging of prostate cancer (PC). We used 6-hydrazinonicotinamide (HYNIC) as bi-functional chelating agent and tricine/ethylenediamine diacetic acid (EDDA) as an… Click to show full abstract
In this study, we introduce a new 99mTc-radiolabeled bombesin derivative for imaging of prostate cancer (PC). We used 6-hydrazinonicotinamide (HYNIC) as bi-functional chelating agent and tricine/ethylenediamine diacetic acid (EDDA) as an exchange co-ligands. Radiolabeling was achieved with high purity and was accompanied with high solution and serum stability. Cellular binding study demonstrated specific binding and internalization of radioconjugate in cultured PC3 cells. In vivo experiments showed fast blood clearance with kidney excretion. Blocking experiments showed decreased uptake of radiopeptide in tumor and pancreas. The results of the imaging using planar SPECT also confirmed suitable tumour uptake for PC3 xenograft nude mice.
Journal Title: Journal of Radioanalytical and Nuclear Chemistry
Year Published: 2018
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