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Adamantan-2-one is an adamantane derivative used as a precursor in the synthesis of different pharmacologically active substances, i.e., memantine hydrochloride which was investigated in one of our previous published papers,… Click to show full abstract
Adamantan-2-one is an adamantane derivative used as a precursor in the synthesis of different pharmacologically active substances, i.e., memantine hydrochloride which was investigated in one of our previous published papers, both as pure compound and in binary mixtures. The aim of our study is to determine the influence of the oxo group regarding the thermal stability of the hydrocarbon structure and also to evaluate possible interactions of the functional groups with various compounds used as excipients. For this purpose, we evaluated the thermal behavior of adamantan-2-one and its compatibility with some excipients used in drug formulations. The pure compounds and the binary mixtures of adamantan-2-one with different excipients were investigated by TG/DTG/HF thermal methods in dynamic air flow, at a heating rate of 10 °C min−1 until 550 °C and by FTIR spectroscopy.
Journal Title: Journal of Thermal Analysis and Calorimetry
Year Published: 2017
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