LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

Kinetics of heterogeneous-induced degradation for artesunate and artemether

Photo from archive.org

This paper presents the results obtained after the investigation of two artemisinin derived sesquiterpenes, namely artesunate and artemether, currently studied for their antitumor properties. The chosen methods of analysis included… Click to show full abstract

This paper presents the results obtained after the investigation of two artemisinin derived sesquiterpenes, namely artesunate and artemether, currently studied for their antitumor properties. The chosen methods of analysis included UATR–FTIR spectroscopy, characterization of the thermal behavior (TG/DTG/HF) in oxidative dynamic atmosphere, and a complete kinetic analysis. The latter was realized using two integral methods (Kissinger–Akahira–Sunose and Flynn–Wall–Ozawa), a differential one (Friedman), and was later completed with the modified NPK method. The study showed that both compounds show similar thermal stability in terms of apparent activation energies and the degradation processes occur in two parallel steps for each compound, this being solely due to chemical transformations.

Keywords: degradation; artesunate artemether; kinetics heterogeneous; induced degradation; heterogeneous induced; degradation artesunate

Journal Title: Journal of Thermal Analysis and Calorimetry
Year Published: 2018

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.