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An efficient and green reaction of isatins, 3-amino-1-phenyl-2-pyrazolin-5-one (3-amine-1H-pyrazole), and $$\beta $$β-diketone in aqueous medium in the presence of $$\hbox {PEG}$$PEG–$$\hbox {SO}_{{3}}\hbox {H}$$SO3H is reported, and a series of novel… Click to show full abstract
An efficient and green reaction of isatins, 3-amino-1-phenyl-2-pyrazolin-5-one (3-amine-1H-pyrazole), and $$\beta $$β-diketone in aqueous medium in the presence of $$\hbox {PEG}$$PEG–$$\hbox {SO}_{{3}}\hbox {H}$$SO3H is reported, and a series of novel spirocompounds was obtained with high yields. The advantages of this reaction were simple procedure, moderate reaction conditions, and wide range of substrates. More importantly, the catalyst $$\hbox {PEG}$$PEG–$$\hbox {SO}_{{3}}\hbox {H}$$SO3H could be recovered for reuse up to five times.Graphical Abstract
Journal Title: Molecular Diversity
Year Published: 2017
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