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Abstract An economical and proficient approach has been developed for the synthesis of chromenopyrimidines via three-component reaction of thiobarbituric acid/barbituric acid, methylarenes and dimedone/1,3-cyclohexanedione by using lemon juice as a… Click to show full abstract
Abstract An economical and proficient approach has been developed for the synthesis of chromenopyrimidines via three-component reaction of thiobarbituric acid/barbituric acid, methylarenes and dimedone/1,3-cyclohexanedione by using lemon juice as a natural, biodegradable catalyst and TBHP as an oxidant. This transformation involves metal-free C–C bond formation via C–H activation of methylarenes under mild reaction conditions. Graphical abstract
Keywords:
formation via;
lemon juice;
bond formation;
synthesis chromenopyrimidines;
via activation
Journal Title: Molecular Diversity
Year Published: 2019
Link to full text (if available)
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Journal Title: Molecular Diversity
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!