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We have designed and synthesized an efficient novel task-specific ionic liquid, 1-(ethylaceto acetate)-1-(2-hydroxyethyl) piperidinium tetrachloroaluminate [EAHEPiPY]+ [AlCl4]–. Its catalytic efficiency was explored for multicomponent reaction of isatin(s), malononitrile, and indole(s)… Click to show full abstract
We have designed and synthesized an efficient novel task-specific ionic liquid, 1-(ethylaceto acetate)-1-(2-hydroxyethyl) piperidinium tetrachloroaluminate [EAHEPiPY]+ [AlCl4]–. Its catalytic efficiency was explored for multicomponent reaction of isatin(s), malononitrile, and indole(s) furnished corresponding 3,3′-disubstituted oxindoles via tandem Knoevenagel/Michael addition reaction in excellent yield at 80 °C in mixed solvent system, water: ethanol (80:20%).Graphical Abstract
Journal Title: Research on Chemical Intermediates
Year Published: 2017
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