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Nanosilica from wheat straw—an agricultural waste—was utilized as a novel and efficient heterogeneous catalyst for synthesis of bioactive pyrano[2,3-c]pyrazole derivatives via one-pot four-component reaction of various aryl aldehydes, hydrazine hydrate,… Click to show full abstract
Nanosilica from wheat straw—an agricultural waste—was utilized as a novel and efficient heterogeneous catalyst for synthesis of bioactive pyrano[2,3-c]pyrazole derivatives via one-pot four-component reaction of various aryl aldehydes, hydrazine hydrate, ethyl acetoacetate, and malononitrile in aqueous medium at 80 °C. The nano-SiO2 extracted from wheat straw was characterized by Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) analysis, particle size analysis, energy-dispersive X-ray (EDX) analysis, and scanning electron microscopy (SEM). All the synthesized pyrano[2,3-c]pyrazoles were characterized by FT-IR spectroscopy, electrospray ionization (ESI) mass spectroscopy (MS), 1H and 13C nuclear magnetic resonance (NMR), and elemental analysis. Additional features of this method include an efficient, rapid, and ecofriendly reaction process, easy workup, high yield, short reaction time, and recyclable green catalyst.Graphical Abstract
Journal Title: Research on Chemical Intermediates
Year Published: 2017
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