The reactions of aldehydes and barbituric acid at low temperatures in magnetized water, as a green-promoting medium, provides 9-substituted-9H-diuracilopyrans in high-to-excellent yields. This method offers the advantages of short reaction… Click to show full abstract
The reactions of aldehydes and barbituric acid at low temperatures in magnetized water, as a green-promoting medium, provides 9-substituted-9H-diuracilopyrans in high-to-excellent yields. This method offers the advantages of short reaction times, simplicity, low costs, high reaction yields, being green, and no need for any organic solvent. Moreover, the influence of magnetized water on the reactivity of the reactants is investigated using molecular dynamics simulations. It is shown that magnetized water has a dramatic impact on the reactivity of the two reactants involved through increase in the strength of the hydrogen bond interactions between them.
               
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