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An efficient synthesis of biaryl diamides via Ullmann coupling reaction catalyzed by CuI in the presence of Cs2CO3 and TBAB

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CuI accompanyied by Cs2CO3 and TBAB was confirmed to be an efficient catalyst combination to promote an Ullmann coupling reaction. It facilitated 2-bromobenzamides to undergo a coupling reaction for the… Click to show full abstract

CuI accompanyied by Cs2CO3 and TBAB was confirmed to be an efficient catalyst combination to promote an Ullmann coupling reaction. It facilitated 2-bromobenzamides to undergo a coupling reaction for the synthesis of symmetrical biaryldiamides in moderate yields at 120 °C under Pd-free conditions.Graphical Abstract

Keywords: coupling reaction; reaction; ullmann coupling; synthesis; cs2co3 tbab

Journal Title: Research on Chemical Intermediates
Year Published: 2018

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