LAUSR

N-(3-oxo-3-morpholino-1-phenyl-propyl) benzo sulfonamide (BMS) (C19H22N2O4S) has been synthesized and characterized by FT-IR, 1H and 13C NMR, and ESI-mass spectrometric methods. The 2-D NMR (COSY, HSQC, DEPT and TOCSY spectra) of BMS is recorded to study the correlation between protons and carbons. The optimized geometry, harmonic vibrational frequencies and infrared intensities are calculated using B3LYP/6-311++(2d,p) basis set on the Gaussian. 13C and 1H NMR chemical shifts are calculated using the gauge independent atomic orbital method with B3LYP/6-311++(2d,p) basis set. The detailed analysis of experimental NMR chemical shifts as well as IR vibrations is supported by quantum chemical calculations using the Gaussian approach. The HOMO and LUMO energy calculation and Mulliken charges were calculated by the DFT approach. The UV–Vis and photoluminescence study confirms the light emitting nature of the molecule. BMS showed better antimicrobial activities against resistant and non-resistant strains. Further, the anticancer activity of the compound is studied against the PC-3 cancer cell line in comparison to mitoxantrone. Comparative docking study of BMS with mitoxantrone and doxorubicin has been carried out on the p53 tumor suppressor-DNA complex. Effective binding is observed at ARG-248, which is an experimentally proved mutated site of the p53 protein.