LAUSR

A series of (2-amino-3-cyano-4H-chromen-4-yl) phosphonic acid diethyl ester derivatives were synthesized from salicylaldehyde, malononitrile and triethylphosphite in ethanol/water (1:1) system using a new dual basic ionic liquid, i.e., 1-[3-(dimethylamino)propyl]-1,4-diazabicyclo[2.2.2]octan-1-ium hydroxide at ambient temperature. The attractive features of this protocol are higher yields (more than 95%), low cost, reduced environmental impact, shorter reaction time, reusability of IL (up to 7 times) and convenience of procedure. The possible bioactivity study was also carried out by using molecular docking study for all the synthesized compounds and molecules can be act as anticancer agent.Graphic abstractSynthesis of some new (2-amino-3-cyano-4H-chromen-4-yl) phosphonic acid diethyl ester derivatives by using new dual basic ionic liquid.