LAUSR

A practical and efficient method for the synthesis of thiazolidine derivatives via Nef-isocyanide three-component reaction using supported phosphoric acid on graphene oxide (GO-H 2 PO 4 ) is described. In this study, a relatively simple method starting with cyclic and acyclic thiourea was employed. The catalyst was characterized using FTIR, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction techniques. Using a combination of acetonitrile as solvent and GO-H 2 PO 4 as a catalytic system, the best results were obtained. All products were characterized using melting point, FTIR, MASS, 1 H NMR, and 13 C NMR techniques. The use of commercially available chemicals, reusability of the catalyst, high yields, decreased environmental hazards, with no need for the separation of stereoisomers, and, consequently, a reduced number of overall steps are the advantages of this approach that make it an appropriate choice at an increased scale.