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An efficient method for the synthesis of highly functionalized piperidines via one-pot domino reaction of β-ketoesters, aromatic aldehydes, and aromatic amines was reported. This multicomponent coupling was catalyzed by TMSI… Click to show full abstract
An efficient method for the synthesis of highly functionalized piperidines via one-pot domino reaction of β-ketoesters, aromatic aldehydes, and aromatic amines was reported. This multicomponent coupling was catalyzed by TMSI in methanol at room temperature, giving desired substituted pyridines in moderate to good yields.
Keywords:
synthesis highly;
highly functionalized;
multicomponent reaction;
catalyzed tmsi
Journal Title: Research on Chemical Intermediates
Year Published: 2020
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Journal Title: Research on Chemical Intermediates
Year Published: 2020
Link to full text (if available)
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recommendations!