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Catalytic olefination of carbonyl steroid derivatives were used to obtain the corresponding 1,1-dibromoalkenes. For this, N-unsubstituted steroid hydrazones were involved into the reaction with tetrabromomethane in the presence of copper(i)… Click to show full abstract
Catalytic olefination of carbonyl steroid derivatives were used to obtain the corresponding 1,1-dibromoalkenes. For this, N-unsubstituted steroid hydrazones were involved into the reaction with tetrabromomethane in the presence of copper(i) chloride. The dibromides can be used for the synthesis of various functionalized steroids by conversion of a dibromomethylidene fragment to the carboxy, amide, and phosphonate groups.
Keywords:
steroid derivatives;
carbonyl steroid;
reaction;
catalytic olefination
Journal Title: Russian Chemical Bulletin
Year Published: 2018
Link to full text (if available)
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Journal Title: Russian Chemical Bulletin
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!