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Abstract2-(2-Hydroxyplienyl)imidazole derivatives were synthesized and tested for antiviral activity against vaccinia virus in Vero cell culture. 1-Methylimidazole 3-oxides, 1-methoxyimidazoles, and 1H-imidazoles showed no activity, whereas some 1-hydroxyimidazole derivatives hold promise,… Click to show full abstract
Abstract2-(2-Hydroxyplienyl)imidazole derivatives were synthesized and tested for antiviral activity against vaccinia virus in Vero cell culture. 1-Methylimidazole 3-oxides, 1-methoxyimidazoles, and 1H-imidazoles showed no activity, whereas some 1-hydroxyimidazole derivatives hold promise, exhibiting antiviral activity and weak cytotoxicity.
Keywords:
activity hydroxy;
antiviral activity;
vaccinia virus;
hydroxy hydroxyphenyl;
activity;
synthesis antiviral
Journal Title: Russian Chemical Bulletin
Year Published: 2019
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Journal Title: Russian Chemical Bulletin
Year Published: 2019
Link to full text (if available)
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recommendations!