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Isoquinolines react with secondary phosphine oxides without catalyst (70–75 °C, 10–15 h, without solvent or in MeCN) to chemo- and regioselectively form previously unknown diadducts, 1,3-bis(diorganylphosphoryl)-1,2,3,4-tetrahydroisoquinolines, in high yields (85–95%). Click to show full abstract
Isoquinolines react with secondary phosphine oxides without catalyst (70–75 °C, 10–15 h, without solvent or in MeCN) to chemo- and regioselectively form previously unknown diadducts, 1,3-bis(diorganylphosphoryl)-1,2,3,4-tetrahydroisoquinolines, in high yields (85–95%).
Keywords:
free regio;
secondary phosphine;
phosphine oxides;
regio chemoselective;
catalyst free
Journal Title: Russian Chemical Bulletin
Year Published: 2020
Link to full text (if available)
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Journal Title: Russian Chemical Bulletin
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!